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son of sevenless : ウィキペディア英語版
son of sevenless

In cell signalling, ''Son of Sevenless'' (''SOS'') refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases.
==History and name==
The gene was so named because the Sos protein that it encoded was found to operate downstream of the ''sevenless'' gene in ''Drosophila melanogaster'' in a Ras/MAP kinase pathway. When ''sevenless'' is mutated or otherwise dysfunctional during development of the fly's ultraviolet light-sensitive compound eye, the seventh, central photoreceptor (R7) of each ommatidium fails to form. Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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